The Gibbs laboratory is focused on the development of novel fluorophores and fluorescence imaging technologies to improve cancer detection and treatment. The main research focuses of the group are on fluorophore development for image-guided surgery, fluorescent labeling of small molecule therapeutics to improve understanding of effective cancer therapy and development of highly multiplexed immunofluorescence imaging technologies to permit deep multiplexed imaging on tissues. Current projects in the Gibbs laboratory include (1) development of near infrared nerve-specific fluorophore to improve nerve sparing during radical prostatectomy, (2) contrast agent and imaging methodology development to improve breast cancer margin assessment in the operating room, (3) design and synthesis of fluorescently labeled small molecule therapeutics for personalized therapy prediction in cancer, and (4) development of improved cyclic immunofluorescence methods to permit up to 50 color staining on a single tissue sample.
The ASE Intern will have the opportunity to pursue a project in any of these 4 research focuses of the lab. The ASE Intern could expect to learn laboratory skills including fluorophore synthesis and purification strategies, cancer cell culture, spectroscopy, fluorescence microscopy, mouse handling and in vivo imaging depending on the project of interest.